General Information

  • ID:  hor002780
  • Uniprot ID:  NA
  • Protein name:  hippocampal cholinergic neurostimulating peptide
  • Gene name:  NA
  • Organism:  Rhyparobia maderae
  • Family:  NA
  • Source:  animal
  • Expression:  central nervous system, locust subesophageal, thoracic, and abdominal ganglia
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  NA
  • GO MF:  NA
  • GO BP:  NA
  • GO CC:  NA

Sequence Information

  • Sequence:  AADISQWAGPL
  • Length:  11
  • Propeptide:  NA
  • Signal peptide:  NA
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Further modulatory actions of baratin in different circuits of the brain and ventral nerve cord
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA
  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
  •    hor002780_AF2.pdbhor002780_ESM.pdb

Physical Information

Mass: 130682 Formula: C51H77N13O16
Absent amino acids: CEFHKMNRTVY Common amino acids: A
pI: 3.75 Basic residues: 0
Polar residues: 2 Hydrophobic residues: 6
Hydrophobicity: 27.27 Boman Index: 88
Half-Life: 4.4 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 98.18
Instability Index: 521.82 Extinction Coefficient cystines: 5500
Absorbance 280nm: 550

Literature

  • PubMed ID:  10842231
  • Title:  Baratin, a Nonamidated Neurostimulating Neuropeptide, Isolated From Cockroach Brain: Distribution and Actions in the Cockroach and Locust Nervous Systems